Minor structural modifications to alchemix influence mechanism of action and pharmacological activity
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چکیده
منابع مشابه
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.
Alchemix is an exemplar of a class of anthraquinone with efficacy against multidrug resistant tumours. We have explored further the mechanism of action of alchemix and investigated the effect of extending its side arm bearing the alkylating functionality with regard to DNA binding and activity against multidrug resistant cancer cells. Increasing the distance between the intercalating chromophor...
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ژورنال
عنوان ژورنال: Biochemical Pharmacology
سال: 2012
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2012.02.017